Omega Isotope is a rare resource in Warframe. It can only be farmed when the Fomorian Invasion event is active in the game. Omega Isotope will only be present on a planet that has a nearby Balor Fomorian. It will drop from enemies as an uncommon resource, but will not appear during Arch-wing missions. The planet will need to have an active Fomorian Sabotage mission located on it to be able to spawn this resource.
How to Get Omega Isotope in Warframe

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Getting the Omega Isotope is easy. All you need to do is perform any mission on a planet with an active Fomorian Sabotage event. As long as it is not an Arch-wing mission, dead enemies can drop the resource. Normal mission nodes, Alerts, Syndicate missions, and Invasions should all drop the resource, once they occur on the planet with the Fomorian Sabotage event.
The best way to get the resource is to do missions with high enemy spawns. Interception, Survival, and Defense missions are all perfect. Isotopes are also treated as a standard resource, so will be affected by resource boosters. Finally, Warframes that can affect loot drops will work on Isotopes. You can use Desecrate on Nekros, Pilfering Swarm with Hydroid, or Pilfering Strangledome with Khora to improve the drop rates.
What To Do With The Isotope
The reason you want to farm up the Isotope is to build the Fomorian Disruptor. This is a special Gear item that you will need for the event. You can purchase the main blueprint from that market for 5,000 Credits. It will take one minute to build in your Foundry, using the following resources:
- Credits – 1250
- Nano Spores – 3500
- Cryotic – 300
- Omega Isotopes – 4
Once you have built the Fomorian Disruptor, you can place it in your Gear Wheel. Then launch the mission against a Balor Fomorian. You cannot launch the mission if it is not in your Gear Wheel. When you reach the Balor Fomorian’s core, the Disruptor will strip the shielding, allowing you to damage it. Only one player needs to use the item, but all players will have it removed from their inventory.
That should be everything you need to know about Omega Isotope in Warframe. Best of luck taking on the Fomorians, Tenno.